Actor Christina Applegate reveals she was misdiagnosed with multiple sclerosis

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Key context: <p>The Married … with Children actor says the news is ‘unnerving’ and ‘really confusing’</p><ul><li><p><a href="https://www.theguardian.com/news/2026/feb/17/sign-up-for-the-breaking-news-us-email-to-get-newsletter-alerts-direct-to-your-inbox?utm_medium=ACQUISITIONS_STANDFIRST&amp;utm_campaign=BN22326&amp;utm_content=signup&amp;utm_term=standfirst&amp;utm_source=GUARDIAN_WEB">Sign up for the Breaking News US newsletter email</a></p></li></ul><p>After becoming a prominent advocate for <a href="https://www.theguardian.com/society/multiple-sclerosis">multiple sclerosis</a> awareness and chronicling her struggles in an <a href="https://www.theguardian.com/books/2026/mar/01/christina-applegate-ms-diagnosis-memoir-autobiography">emotional memoir</a> published in March, the Emmy-winning actor Christina Applegate has revealed she does not have the debilitating autoimmune disease after all.</p><p>Applegate, 54, made the stunning announcement in an episode of her podcast MeSsy, recorded with fellow actor Jamie-Lynn Sigler, posted <a href="https://www.youtube.com/watch?v=UvDm3V8pVSQ">to YouTube</a> on Tuesday.</p> <a href="https://www.theguardian.com/tv-and-radio/2026/oct/20/christina-applegate-ms-misdiagnosed">Continue reading...</a> This development from The Guardian highlights ongoing changes in the sector.